Welcome to the Cho-Park Laboratory of Protein Homeostasis at Penn.
We are located on the 10th floor of the state of the art Smilow Center for Translational Research on Penn campus.
We take a multi-pronged interdisciplinary approaches (Biochemistry, Biophysics, Cell Biology, Genetics and Molecular Biology) to dissect the role of protein homeostasis in vivo and in disease models. We are particularly interested in uncovering the intimate link that must exist between protein synthesis and proteasome regulation.
It is our belief that knowledge gained from our endeavors will not only advance the basic understanding of protein homeostasis in the broader context of biology, but will also open up new therapeutic opportunities against those diseases that arise secondary to accumulation of misfolded “toxic” proteins such as Cancer, Amyotrophic Lateral Sclerosis, Retinitis Pigmentosa and Alzheimer’s disease, to alleviate human sufferings.
If you are interested in joining us or simply interested in our work, please leave us a message and we will get back to you as soon as possible.